Overview

  • Product nameAnti-TIP30 antibody
    See all TIP30 primary antibodies
  • Description
    Rabbit polyclonal to TIP30
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-192 of Human TIP30. (Uniprot: Q9BUP3)

  • Positive control
    • A431 cell lysate and HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 27 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • FunctionOxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
  • Tissue specificityUbiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
  • DomainUnique C-terminus confers high proteasome-dependent instability to isoform 2.
  • Cellular localizationCytoplasm. Nucleus envelope.
  • Information by UniProt
  • Database links
  • Alternative names
    • 30 kDa HIV 1 TAT interacting protein antibody
    • 30 kDa HIV-1 TAT-interacting protein antibody
    • 30 kDa HIV1 TAT interacting protein antibody
    • CC3 antibody
    • FLJ26963 antibody
    • HIV 1 Tat interacting protein 2 30kDa antibody
    • HIV 1 Tat interacting protein 2 antibody
    • HIV-1 TAT-interactive protein 2 antibody
    • HTAI2_HUMAN antibody
    • HTATIP 2 antibody
    • HTATIP2 antibody
    • Oxidoreductase HTATIP2 antibody
    • SDR44U1 antibody
    • Short chain dehydrogenase/reductase family 44U member 1 antibody
    • Tat interacting protein (30kDa) antibody
    see all

Anti-TIP30 antibody images

  • ab125726, at 1/500 dilution, staining TIP30 (Green) in Paraformaldehyde-fixed HeLa cells by Immunocytochemistry/Immunofluorescence.
  • All lanes : Anti-TIP30 antibody (ab125726) at 1/5000 dilution

    Lane 1 : A431 lysate at 30 µg
    Lane 2 : HeLa lysate at 30 µg


    Predicted band size : 27 kDa

References for Anti-TIP30 antibody (ab125726)

ab125726 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"