Overview

  • Product name
    Tiratricol (TRIAC)
  • Description
    Thyroid hormone analog
  • Alternative names
    • TRIAC
  • Biological description
    Thyroid hormone analog. Shows hepatoselectivity. Suppresses thyroid-stimulating hormone production and shows antiobesogenic effects in vivo. Orally active.
  • Purity
    > 97%

Properties

  • Chemical name
    2-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
  • Molecular weight
    621.93
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C14H9I3O4
  • CAS Number
    51-24-1
  • PubChem identifier
    5803
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Senese R  et al. Thyroid: biological actions of 'nonclassical' thyroid hormones. J Endocrinol 221:R1-12 (2014). Read more (PubMed: 24464019) »
  • Horn S  et al. Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. Endocrinology 154:968-79 (2013). Read more (PubMed: 23307789) »
  • Zhang B  et al. Thyroid hormone analogue stimulates keratinocyte proliferation but inhibits cell differentiation in epidermis. Int J Immunopathol Pharmacol 25:859-69 (0). Read more (PubMed: 23298477) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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