Overview

  • Product name
    Anti-TLK1 antibody - C-terminal
    See all TLK1 primary antibodies
  • Description
    Rabbit polyclonal to TLK1 - C-terminal
  • Tested applications
    Suitable for: ELISA, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) conjugated to KLH

  • Positive control
    • HL-60 cell lysate and human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab71744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 87 kDa (predicted molecular weight: 87 kDa).

Target

  • Function
    Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
  • Tissue specificity
    Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • PKU beta antibody
    • PKU-beta antibody
    • serine threonine protein kinase antibody
    • Serine/threonine protein kinase tousled like 1 antibody
    • Serine/threonine-protein kinase tousled-like 1 antibody
    • SNARE protein kinase SNAK antibody
    • Tlk1 antibody
    • TLK1_HUMAN antibody
    • Tousled like kinase 1 antibody
    • Tousled-like kinase 1 antibody
    see all

Images

  • Anti-TLK1 antibody - C-terminal (ab71744) at 1/100 dilution + HL-60 cell lysate at 12.5 µg

    Predicted band size : 87 kDa
    Observed band size : 87 kDa
  • ab71744 at 1/50 dilution, staining TLK in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.

References

ab71744 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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