• Product nameAnti-TLK1 antibody [EPR2886]
    See all TLK1 primary antibodies
  • Description
    Rabbit monoclonal [EPR2886] to TLK1
  • Tested applicationsSuitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human TLK1 (UniProt Q9UKI8).

  • Positive control
    • HeLa and A431 cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


Associated products


Our Abpromise guarantee covers the use of ab108987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 86 kDa (predicted molecular weight: 87 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notesIs unsuitable for ICC or IHC-P.
  • Target

    • FunctionRapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
    • Tissue specificityWidely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
    • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • PKU beta antibody
      • PKU-beta antibody
      • serine threonine protein kinase antibody
      • Serine/threonine protein kinase tousled like 1 antibody
      • Serine/threonine-protein kinase tousled-like 1 antibody
      • SNARE protein kinase SNAK antibody
      • Tlk1 antibody
      • TLK1_HUMAN antibody
      • Tousled like kinase 1 antibody
      • Tousled-like kinase 1 antibody
      see all

    Anti-TLK1 antibody [EPR2886] images

    • All lanes : Anti-TLK1 antibody [EPR2886] (ab108987) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : A431 cell lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 87 kDa
      Observed band size : 86 kDa (why is the actual band size different from the predicted?)

    References for Anti-TLK1 antibody [EPR2886] (ab108987)

    ab108987 has not yet been referenced specifically in any publications.

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