FunctionRapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
Tissue specificityWidely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Detection of TLK2 by Western Blot of Immunprecipitate.
ab74335 at 1µg/ml staining TLK2 in 293 whole cell lysate immunoprecipitated using ab74335 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.
References for Anti-TLK2 antibody (ab74335)
has not yet been referenced specifically in any publications.
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