Overview

  • Product name
  • Description
    Rabbit polyclonal to TLL1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human TLL1 aa 874-901 (C terminal) conjugated to keyhole limpet haemocyanin.
    Database link: O43897

  • Positive control
    • ZR-75-1 cell line lysate, Human prostate carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab107743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 115 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
  • Involvement in disease
    Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:613087]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
  • Sequence similarities
    Belongs to the peptidase M12A family.
    Contains 5 CUB domains.
    Contains 2 EGF-like domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ASD6 antibody
    • TLL antibody
    • TLL1 antibody
    • TLL1_HUMAN antibody
    • Tolloid like 1 antibody
    • Tolloid-like protein 1 antibody
    see all

Images

  • Anti-TLL1 antibody (ab107743) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

    Predicted band size : 115 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemistry analysis in formalin fixed and paraffin embedded Human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. ab107743 at a dilution of 1/50.

References

ab107743 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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