Overview

  • Product nameAnti-TLR1 antibody [EPR2075]
    See all TLR1 primary antibodies
  • Description
    Rabbit monoclonal [EPR2075] to TLR1
  • Tested applicationsSuitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues on the extracellular region of human TLR1

  • Positive control
    • WB: Daudi and Ramos cell lysates. Flow Cyt: Daudi cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab68158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
Flow Cyt
  • Application notesFlow Cyt: 1/60.
    IP: 1/40.
    WB: 1/1000 - 1/2000. Detects a band of approximately 90 and 125 kDa (predicted molecular weight: 90 kDa).

    Is unsuitable for ICC or IHC-P.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionParticipates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    • Tissue specificityUbiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
    • Sequence similaritiesBelongs to the Toll-like receptor family.
      Contains 12 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 TIR domain.
    • Cellular localizationCell membrane. Cytoplasmic vesicle > phagosome membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD281 antibody
      • CD281 antigen antibody
      • KIAA0012 antibody
      • LPRS5 antibody
      • rsc786 antibody
      • TIL antibody
      • TIL. LPRS5 antibody
      • Tlr1 antibody
      • TLR1_HUMAN antibody
      • Toll (Drosophila) homolog antibody
      • Toll like receptor 1 antibody
      • Toll-like receptor 1 antibody
      • Toll/interleukin-1 receptor-like protein antibody
      see all

    Anti-TLR1 antibody [EPR2075] images

    • All lanes : Anti-TLR1 antibody [EPR2075] (ab68158) at 1/1000 dilution

      Lane 1 : Daudi cell lysate
      Lane 2 : Ramos cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 90 kDa
      Observed band size : 90 kDa
      Additional bands at : 125 kDa. We are unsure as to the identity of these extra bands.
    • Flow cytometric analysis of TLR1 in Daudi cells using ab68158 at 1/60 dilution (pink) or a rabbit IgG (green).

    References for Anti-TLR1 antibody [EPR2075] (ab68158)

    ab68158 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab68158.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"