Overview

  • Product nameAnti-TLR2 antibody
    See all TLR2 primary antibodies
  • Description
    Chicken polyclonal to TLR2
  • Tested applicationsSuitable for: WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Amino acids 215-410 of TLR2.

Properties

Applications

Our Abpromise guarantee covers the use of ab14275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 86 kDa.
Neutralising 1/100.

Target

  • FunctionCooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • Tissue specificityHighly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • Sequence similaritiesBelongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Post-translational
    modifications
    Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

Anti-TLR2 antibody images

  • Anti-TLR2 antibody (ab14275) at 1/2000 dilution + Fusion protein derived in E.Coli

    Predicted band size : 86 kDa

References for Anti-TLR2 antibody (ab14275)

This product has been referenced in:
  • Yuki T  et al. Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes. J Immunol 187:3230-7 (2011). Neutralising ; Human . Read more (PubMed: 21841130) »
  • Loryman C & Mansbridge J Inhibition of keratinocyte migration by lipopolysaccharide. Wound Repair Regen 16:45-51 (2008). Neutralising ; Human . Read more (PubMed: 18211578) »

See all 2 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"