Overview

  • Product nameAnti-TLR2 antibody [TL2.1] (FITC)
    See all TLR2 primary antibodies
  • Description
    Mouse monoclonal [TL2.1] to TLR2 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Tested applicationsSuitable for: Flow Cyt, IP, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    CHO cells transfected with human TLR2 cDNA

  • General notesAvoid temparature fluctuations.

Properties

Applications

Our Abpromise guarantee covers the use of ab13553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 2-5µg for 106 cells. ab91362-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IP Use a concentration of 2 - 5 µg/ml.
ICC Use a concentration of 10 µg/ml.

Target

  • FunctionCooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • Tissue specificityHighly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • Sequence similaritiesBelongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Post-translational
    modifications
    Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD282 antibody
    • CD282 antigen antibody
    • TIL 4 antibody
    • TIL4 antibody
    • TLR 2 antibody
    • TLR2 antibody
    • TLR2_HUMAN antibody
    • Toll like receptor 2 antibody
    • Toll like receptor 2 precursor antibody
    • Toll-like receptor 2 antibody
    • Toll/interleukin 1 receptor like 4 antibody
    • Toll/interleukin 1 receptor like protein 4 antibody
    • Toll/interleukin receptor like protein 4 antibody
    • Toll/interleukin-1 receptor-like protein 4 antibody
    see all

References for Anti-TLR2 antibody [TL2.1] (FITC) (ab13553)

This product has been referenced in:
  • Burgener IA & Jungi TW Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 124:184-91 (2008). Read more (PubMed: 18439687) »
  • Do JE  et al. Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford) 47:840-8 (2008). Read more (PubMed: 18411217) »

See all 13 Publications for this product

Product Wall

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ab114070 is a mouse monoclonal in which human TLR2 was expressed. That is, the antibodies from mice were raised against human TLR2 full length.

ab13553: As stated on the data sheet CHO cells transfected...

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Thank you for contacting us.

As far as I can tell, these two antibodies are very similar and should give the same results. With regards to their specificity, ab114070 was raised against human TLR2 whereas, ab13553 was raised against human TL...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"