Overview

  • Product nameAnti-TLR7 antibody
    See all TLR7 primary antibodies
  • Description
    Mouse monoclonal to TLR7
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: ARWFPKTLPC DVTLDVPKNH VIVDCTDKHL TEIPGGIPTN TTNLTLTINH IPDISPASFH RLDHLVEIDF RCNCVPIPLG SKNNMCIKRL QIKPRSFSGL T, corresponding to amino acids 27-127 of Human TLR7 (NP_057646) with a proprietary tag.

  • Positive control
    • Daoy cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 121 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionKey component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • Tissue specificityDetected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
  • Sequence similaritiesBelongs to the Toll-like receptor family.
    Contains 27 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Cellular localizationEndoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt
  • Database links
  • Alternative names
    • PRO285 antibody
    • TLR 7 antibody
    • Tlr7 antibody
    • TLR7_HUMAN antibody
    • Toll like receptor 7 antibody
    • Toll-like receptor 7 antibody
    • UNQ248 antibody
    see all

Anti-TLR7 antibody images

  • Anti-TLR7 antibody (ab89509) at 5 µg/ml + Daoy cell lysate at 50 µg

    Predicted band size : 121 kDa
  • Anti-TLR7 antibody (ab89509) at 5 µg/ml + immunogen (101aa recombinant fragment with a tag of 26kDa) at 0.2 µg

    Predicted band size : 121 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

References for Anti-TLR7 antibody (ab89509)

ab89509 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"