The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 µg/ml. Predicted molecular weight: 121 kDa.
Use 1-2µg for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionKey component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Tissue specificityDetected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Sequence similaritiesBelongs to the Toll-like receptor family. Contains 27 LRR (leucine-rich) repeats. Contains 1 TIR domain.
Cellular localizationEndoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Flow cytometric analysis of TLR7 antibody in Human monocytes using 2µg of ab107605 (red) and 2µg of Mouse IgG1 isotype control antibody (green). An anti-Mouse IgG PE conjugated secondary antibody.
References for Anti-TLR7 antibody [IMG4G6] (ab107605)
has not yet been referenced specifically in any publications.
Publishing research using ab107605? Please let us know so that we can cite the reference in this datasheet.
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