Overview

  • Product nameAnti-TLR8 antibody [44C143]
    See all TLR8 primary antibodies
  • Description
    Mouse monoclonal [44C143] to TLR8
  • Tested applicationsSuitable for: WB, IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within amino acids 750-850 of Human TLR8

  • Positive control
    • Human brain cortex, Human spleen, 293 transfected with human TLR8, and Ramos cells

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab85859 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 120 kDa.
IHC-P Use a concentration of 5 µg/ml.
Flow Cyt Use 0.5µg for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionKey component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • Tissue specificityDetected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
  • Sequence similaritiesBelongs to the Toll-like receptor family.
    Contains 23 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 288 antibody
    • CD288 antibody
    • CD288 antigen antibody
    • MGC119599 antibody
    • MGC119600 antibody
    • TLR 8 antibody
    • Tlr8 antibody
    • TLR8_HUMAN antibody
    • Toll like receptor 8 antibody
    • Toll-like receptor 8 antibody
    see all

Anti-TLR8 antibody [44C143] images

  • ab85859 at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded brain cortex
  • ab85859 at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded spleen tissue
  • Anti-TLR8 antibody [44C143] (ab85859) at 2 µg/ml + 293 cell lysate transfected with Human TLR8

    Predicted band size : 120 kDa
    Observed band size : 120 kDa
  • ab85859 at 0.5µg in 1x106 Ramos cells
    Shaded histogram represents Ramos cells without antibody; green represents isotype control; purple represents TLR8 antibody.

References for Anti-TLR8 antibody [44C143] (ab85859)

ab85859 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"