Anti-TMC6 antibody (ab67325)

Overview

  • Product name
  • Description
    Rabbit polyclonal to TMC6
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    a 14 amino acid synthetic peptide from near the amino terminus of human TMC6.

  • Positive control
    • A20 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab67325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Relevance
    Defects in TMC6 are a cause of epidermodysplasia verruciformis, a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. TMC6 is expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. There are four named isoforms.
  • Cellular localization
    Endoplasmic reticulum membrane; Multi-pass membrane protein
  • Database links
  • Alternative names
    • Epidermodysplasia verruciformis protein 1 antibody
    • EV1 antibody
    • EVER1 antibody
    • EVIN1 antibody
    • LAK 4P antibody
    • LAK4P antibody
    • Protein LAK 4 antibody
    • Protein LAK4 antibody
    • Transmembrane channel like protein 6 antibody
    see all

Anti-TMC6 antibody images

  • Lane 1 : Anti-TMC6 antibody (ab67325) at 1 µg/ml
    Lane 2 : Anti-TMC6 antibody (ab67325) at 2 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 90 kDa
    Observed band size : 90 kDa
  • ab67325 at 2.5 µg/ml staining TMC6 in human spleen tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

References for Anti-TMC6 antibody (ab67325)

ab67325 has not yet been referenced specifically in any publications.

Product Wall

Application
Immunocytochemistry/ Immunofluorescence
Sample
Chinese Hamster Cell (CHO)
Specification
CHO
Fixative
Formaldehyde
Permeabilization
Yes - triton
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10µg/mL · Temperature: 25°C
Username

Abcam user community

Verified customer

Submitted Apr 15 2013

Thank you for your inquiry.

Unfortunately, we are not able to release the immunogen sequence for ab67325 and ab69859 as it is proprietary information.

However, I can tell you that ab67325 is against a peptide from within xxxxx of ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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