Overview

  • Product nameAnti-TMEFF2 antibody
    See all TMEFF2 primary antibodies
  • Description
    Mouse monoclonal to TMEFF2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Cow, Human
  • Immunogen

    Recombinant fragment: SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CD, corresponding to amino acids 201-292 of Human TMEFF2 protein (NP_057276)

  • Positive control
    • Recombinant tagged human TMEFF2 protein fragment (the immunogen)

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab77038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    WB: 1/500 - 1/1000. Predicted molecular weight: 41 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
    • Tissue specificityHighly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
    • Sequence similaritiesBelongs to the tomoregulin family.
      Contains 1 EGF-like domain.
      Contains 2 Kazal-like domains.
    • Post-translational
      modifications
      N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
      A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
    • Cellular localizationSecreted and Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cancer/testis antigen family 120 member 2 antibody
      • CT120.2 antibody
      • HPP 1 antibody
      • HPP1 antibody
      • Hyperplastic polyposis protein 1 antibody
      • TEFF 2 antibody
      • TEFF2 antibody
      • TEFF2_HUMAN antibody
      • TENB 2 antibody
      • TENB2 antibody
      • TMEFF2 antibody
      • Tomoregulin antibody
      • Tomoregulin-2 antibody
      • TPEF antibody
      • TR 2 antibody
      • TR antibody
      • TR-2 antibody
      • Transmembrane protein containing epidermal growth factor and follistatin domains antibody
      • Transmembrane protein TENB2 antibody
      • Transmembrane protein with EGF like and two follistatin like domains 2 antibody
      • Transmembrane protein with EGF-like and two follistatin-like domains antibody
      see all

    Anti-TMEFF2 antibody images

    • Anti-TMEFF2 antibody (ab77038) at 1/500 dilution + recombinant tagged human TMEFF2 protein (the immunogen) at 0.2 µg

      Secondary
      Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

      Predicted band size : 41 kDa
      Observed band size : 41 kDa

    References for Anti-TMEFF2 antibody (ab77038)

    ab77038 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77038.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"