Overview

  • Product name
  • Description
    Rabbit polyclonal to TMEM106B
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 205-254 (AEEMSYMYDF CTLLSIKVHN IVLMMQVTVT TAYFGHSEQI SQERYQYVDC) of Mouse TMEM106B (NP_082268).

  • Positive control
    • Mouse brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Tissue specificity
    Expressed in frontal cortex.
  • Involvement in disease
    Note=TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.
  • Sequence similarities
    Belongs to the TMEM106 family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2310036D22Rik antibody
    • 5830455K21Rik antibody
    • 6430519M21Rik antibody
    • AI428776 antibody
    • AI661344 antibody
    • FLJ11273 antibody
    • LRRGT00101 antibody
    • MGC33727 antibody
    • MGC94135 antibody
    • T106B_HUMAN antibody
    • Tmem106b antibody
    • Transmembrane protein 106B antibody
    see all

Images

  • Anti-TMEM106B antibody (ab116023) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 31 kDa

References

ab116023 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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