Overview

  • Product name
    Anti-TMEM110 antibody
  • Description
    Rabbit polyclonal to TMEM110
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Cat
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50 of Human TMEM110 (NP_940965).

  • Positive control
    • 721_B cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab98190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the STIMATE family.
  • Domain
    The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
  • Cellular localization
    Endoplasmic reticulum membrane. Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable).
  • Information by UniProt
  • Database links
  • Alternative names
    • STIM-activating enhancer encoded by TMEM110 antibody
    • STIMA_HUMAN antibody
    • STIMATE antibody
    • Store-operated calcium entry regulator STIMATE antibody
    • Tmem110 antibody
    • Transmembrane protein 110 antibody
    see all

Anti-TMEM110 antibody images

  • Anti-TMEM110 antibody (ab98190) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 33 kDa

References for Anti-TMEM110 antibody (ab98190)

ab98190 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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