• Product nameAnti-TMEM127 antibody
    See all TMEM127 primary antibodies
  • Description
    Rabbit polyclonal to TMEM127
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 1-50 of Human TMEM127 (NP_060319.1)

  • Positive control
    • HeLa, 293T, Jurkat, NIH3T3 whole cell lysates


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH: 7-8
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab123516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 26 kDa.
IP Use at 2-10 µg/mg of lysate.


  • FunctionControls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in TMEM127 are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
  • Sequence similaritiesBelongs to the TMEM127 family.
  • Cellular localizationCell membrane. Cytoplasm. Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ20507 antibody
    • FLJ22257 antibody
    • TM127_HUMAN antibody
    • Tmem127 antibody
    • Transmembrane protein 127 antibody
    see all

Anti-TMEM127 antibody images

  • All lanes : Anti-TMEM127 antibody (ab123516) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : 293T whole cell lysate at 50 µg
    Lane 4 : Jurkat whole cell lysate at 50 µg
    Lane 5 : NIH3T3 whole cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 26 kDa

    Exposure time : 3 minutes
  • Detection of TMEM127 by Western Blot of Immunprecipitate.
    Lane 1: ab123516 at 1µg/ml staining TMEM127 in HeLa whole cell lysate immunoprecipitated using ab123516 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Lane 2: Control IgG
    Detection: Chemiluminescence with exposure time of 30 seconds.

References for Anti-TMEM127 antibody (ab123516)

ab123516 has not yet been referenced specifically in any publications.

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