Overview

  • Product nameAnti-TMEM127 antibody
    See all TMEM127 primary antibodies
  • Description
    Rabbit polyclonal to TMEM127
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide derived from within residues:

    LSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQ

    , corresponding to amino acids 107-156 of Human TMEM127

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab80846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionControls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in TMEM127 are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
  • Sequence similaritiesBelongs to the TMEM127 family.
  • Cellular localizationCell membrane. Cytoplasm. Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ20507 antibody
    • FLJ22257 antibody
    • TM127_HUMAN antibody
    • Tmem127 antibody
    • Transmembrane protein 127 antibody
    see all

Anti-TMEM127 antibody images

  • Anti-TMEM127 antibody (ab80846) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 52 kDa. We are unsure as to the identity of these extra bands.

References for Anti-TMEM127 antibody (ab80846)

ab80846 has not yet been referenced specifically in any publications.

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