The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa.
Use a concentration of 20 µg/ml.
Use a concentration of 5 µg/ml.
Use at an assay dependent concentration.
FunctionCan influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.
Tissue specificityHighly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.
Cellular localizationCell junction > adherens junction. Cell membrane. Co-localizes with the beta-catenin adherins.