Overview

  • Product name
  • Description
    Rabbit polyclonal to TMEM59
  • Specificity
    Multiple isoforms of TMEM59 are known to exist. This antibody is predicted to not cross-react with other TMEM family members.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A 16 amino acid peptide near amino terminus of Human TMEM59 (NP_004863)

  • Positive control
    • Human Kidney Tissue Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 36 kDa.
ICC Use a concentration of 2.5 µg/ml.

Target

  • Function
    Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
  • Sequence similarities
    Belongs to the TMEM59 family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C1orf8 antibody
    • HSPC001 antibody
    • Liver membrane-bound protein antibody
    • TMEM59 antibody
    • TMEM59 transmembrane protein 59 antibody
    • TMM59_HUMAN antibody
    • Transmembrane protein 59 antibody
    see all

Images

  • Immunofluorescence of TMEM59 in Human kidney tissue with ab105417 at 20 ug/mL.
  • All lanes : Anti-TMEM59 antibody (ab105417) at 1 µg/ml

    Lane 1 : Human kidney tissue lysate
    Lane 2 : Human kidney tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 36 kDa
  • Immunohistochemistry of TMEM59 in human kidney tissue with ab105417 at 2.5 µg/ml.

References

ab105417 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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