Overview

  • Product name
  • Description
    Rabbit polyclonal to TMEM70
  • Specificity
    Two isoforms of TMEM70 are known to exist; ab106654 will only recognize Isoform 1. ab106654 is predicted not to cross-react with other TMEM proteins.
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 14 amino acid synthetic peptide near the center of Human TMEM70 (NP_060336).

  • Positive control
    • Human liver tissue lysate; Rat liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab106654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 29 kDa.

Target

  • Function
    Involved in biogenesis of mitochondrial ATP synthase.
  • Involvement in disease
    Defects in TMEM70 are a cause of mitochondrial encephalocardiomyopathy neonatal due to ATP synthase deficiency (MT-ATPSD) [MIM:604273]; also known as ATPase deficiency. A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
  • Sequence similarities
    Belongs to the TMEM70 family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ20533 antibody
    • MC5DN2 antibody
    • OTTHUMP00000226855 antibody
    • OTTHUMP00000226856 antibody
    • TMEM70 antibody
    • TMM70_HUMAN antibody
    • Transmembrane protein 70 antibody
    • Transmembrane protein 70 mitochondrial antibody
    • Transmembrane protein 70, mitochondrial antibody
    see all

Images

  • Immunofluorescence of TMEM70 in rat liver tissue with ab106654 at 20 ug/mL.

  • Anti-TMEM70 antibody (ab106654) at 1 µg/ml + Human liver tissue lysate at 15 µg

    Predicted band size : 29 kDa
  • ab106654, at 5 µg/ml, staining TMEM70 in Rat liver tissue by Immunohistochemistry.

References

This product has been referenced in:
  • de Souza AP  et al. Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach. Proteome Sci 13:32 (2015). Read more (PubMed: 26633942) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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