Overview

  • Product name
  • Description
    Rabbit polyclonal to TMPRSS3
  • Specificity
    This antibody reacts specifically with human TMPRSS3.
  • Tested applications
    Suitable for: WBmore details
  • Immunogen

    A 15 residue synthetic peptide derived from specific domain of human TMPRSS3 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab24158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 49 kDa.

Target

  • Function
    Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
  • Tissue specificity
    Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
  • Involvement in disease
    Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 LDL-receptor class A domain.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • Post-translational
    modifications
    Undergoes autoproteolytic activation.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Alternative names
    • Deafness autosomal recessive 10 antibody
    • DFNB10 antibody
    • DFNB8 antibody
    • ECHOS1 antibody
    • Gene similar to transmembrane serine protease antibody
    • MGC130589 antibody
    • Serine protease TADG-12 antibody
    • si:dz69g10.3 antibody
    • TADG12 antibody
    • TMPRSS 3 antibody
    • TMPRSS3 antibody
    • TMPS3_HUMAN antibody
    • Transmembrane protease serine 3 antibody
    • Tumor associated differentially expressed gene 12 protein antibody
    • Tumor-associated differentially-expressed gene 12 protein antibody
    • UNQ323/PRO382 antibody
    see all

Images

  • All lanes : Anti-TMPRSS3 antibody (ab24158)

    Lane 1 : total extract from 293T cells transfected with pHATMPRSS3
    Lane 2 : total extract from 293T cells transfected with pHA (empty vector)

    Lysates/proteins at 40 µg per lane.


    Predicted band size : 49 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

References

ab24158 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your patience. I heard back from the lab regarding ab24158:  There is no homology with mouse. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Thank you for your enquiry. This product was raised in rabbit against a mixture of two synthetic peptides : NH2-MGENDPPAVEAPFSFC-COOH (amino acids 1-16 of human TMPRSS3) and NH2-CFLDWIHEQMERDLKT-COOH (amino acids 439-454of human TMPRSS3). As we a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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