Overview

  • Product name
  • Description
    Goat polyclonal to TMPRSS3
  • Specificity
    This antibody is expected to recognise all four reported isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Orangutan
  • Immunogen

    Synthetic peptide:

    C-EKIVYHSKYKPKR

    , corresponding to internal sequence amino acids 288-300 of Human TMPRSS3.

  • Positive control
    • A431 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab65947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

    Peptide ELISA: antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
    • Tissue specificity
      Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
    • Involvement in disease
      Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
      Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].
    • Sequence similarities
      Belongs to the peptidase S1 family.
      Contains 1 LDL-receptor class A domain.
      Contains 1 peptidase S1 domain.
      Contains 1 SRCR domain.
    • Post-translational
      modifications
      Undergoes autoproteolytic activation.
    • Cellular localization
      Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deafness autosomal recessive 10 antibody
      • DFNB10 antibody
      • DFNB8 antibody
      • ECHOS1 antibody
      • Gene similar to transmembrane serine protease antibody
      • MGC130589 antibody
      • Serine protease TADG-12 antibody
      • si:dz69g10.3 antibody
      • TADG12 antibody
      • TMPRSS 3 antibody
      • TMPRSS3 antibody
      • TMPS3_HUMAN antibody
      • Transmembrane protease serine 3 antibody
      • Tumor associated differentially expressed gene 12 protein antibody
      • Tumor-associated differentially-expressed gene 12 protein antibody
      • UNQ323/PRO382 antibody
      see all

    Anti-TMPRSS3 antibody images

    • Anti-TMPRSS3 antibody (ab65947) at 0.3 µg/ml + A431 cell lysates at 35 µg

      Predicted band size : 49 kDa
      Observed band size : 49 kDa

    References for Anti-TMPRSS3 antibody (ab65947)

    ab65947 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab65947.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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