Recombinant
RabMAb

Anti-TMPRSS3 antibody [EPR7048] (ab167160)

Overview

  • Product name
    Anti-TMPRSS3 antibody [EPR7048]
    See all TMPRSS3 primary antibodies
  • Description
    Rabbit monoclonal [EPR7048] to TMPRSS3
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IF, Flow Cytmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    A synthetic peptide corresponding to extracellular C-terminal residues in Human TMPRSS3 was used as an immunogen. (The amino acid sequence is considered to be commercially sensitive.)

  • Positive control
    • HeLa, PC-12 and A431 cell lysates. Human thyroid gland papillary carcinoma tissue. A431 cells.
  • General notes

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab167160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 49 kDa.
IHC-P 1/100 - 1/250.
ICC/IF 1/250 - 1/500.
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
    • Tissue specificity
      Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
    • Involvement in disease
      Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
      Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].
    • Sequence similarities
      Belongs to the peptidase S1 family.
      Contains 1 LDL-receptor class A domain.
      Contains 1 peptidase S1 domain.
      Contains 1 SRCR domain.
    • Post-translational
      modifications
      Undergoes autoproteolytic activation.
    • Cellular localization
      Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deafness autosomal recessive 10 antibody
      • DFNB10 antibody
      • DFNB8 antibody
      • ECHOS1 antibody
      • Gene similar to transmembrane serine protease antibody
      • MGC130589 antibody
      • Serine protease TADG-12 antibody
      • si:dz69g10.3 antibody
      • TADG12 antibody
      • TMPRSS 3 antibody
      • TMPRSS3 antibody
      • TMPS3_HUMAN antibody
      • Transmembrane protease serine 3 antibody
      • Tumor associated differentially expressed gene 12 protein antibody
      • Tumor-associated differentially-expressed gene 12 protein antibody
      • UNQ323/PRO382 antibody
      see all

    Images

    • ab167160 showing +ve staining in Human cervical carcinoma.
    • ab167160 showing +ve staining in Human normal tonsil.
    • ab167160 showing +ve staining in Human lung adenocarcinoma.
    • ab167160 showing +ve staining in Human normal kidney.
    • ab167160 showing +ve staining in Human normal colon.
    • ab167160 showing +ve staining in Human breast carcinoma.
    • All lanes : Anti-TMPRSS3 antibody [EPR7048] (ab167160) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : PC-12 cell lysate
      Lane 3 : A431 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 49 kDa
    • Immunohistochemical analysis of paraffin embedded Human thyroid gland papillary carcinoma tissue labeling TMPRSS3 with ab167160 at a 1/100 dilution.
    • Immunocytochemical analysis of A431 cells labeling TMPRSS3 with ab167160 at a 1/250 dilution.

    References

    ab167160 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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