Overview

  • Product nameAnti-TMS1 antibody
    See all TMS1 primary antibodies
  • Description
    Mouse polyclonal to TMS1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human TMS1 protein (NP_037390.2)

  • Positive control
    • Human kidney tissue lysate. Human spleen tissue lysate. TMS1 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa.

Target

  • FunctionPromotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificityWidely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
  • Sequence similaritiesContains 1 CARD domain.
    Contains 1 DAPIN domain.
  • DomainInteracts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localizationCytoplasm. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptosis associated speck like protein containing a CARD antibody
    • Apoptosis-associated speck-like protein containing a CARD antibody
    • ASC antibody
    • ASC_HUMAN antibody
    • CARD 5 antibody
    • CARD5 antibody
    • Caspase recruitment domain containing protein 5 antibody
    • Caspase recruitment domain protein 5 antibody
    • Caspase recruitment domain-containing protein 5 antibody
    • hASC antibody
    • MGC10332 antibody
    • PYCARD antibody
    • PYD and CARD domain containing antibody
    • PYD and CARD domain containing protein antibody
    • PYD and CARD domain-containing protein antibody
    • Target of methylation induced silencing 1 antibody
    • Target of methylation-induced silencing 1 antibody
    • TMS 1 antibody
    • TMS antibody
    • TMS1 antibody
    see all

Anti-TMS1 antibody images

  • Anti-TMS1 antibody (ab89611) at 1 µg/ml + Human kidney tissue lysate at 50 µg

    Predicted band size : 22 kDa
    Observed band size : 24 kDa (why is the actual band size different from the predicted?)
  • Anti-TMS1 antibody (ab89611) at 1 µg/ml + Human spleen tissue lysate at 50 µg

    Predicted band size : 22 kDa
    Observed band size : 23 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-TMS1 antibody (ab89611) at 1 µg/ml

    Lane 1 : TMS1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 22 kDa
    Observed band size : 22 kDa

References for Anti-TMS1 antibody (ab89611)

ab89611 has not yet been referenced specifically in any publications.

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