Overview

  • Product nameAnti-TNF beta antibody [EP1113Y]
    See all TNF beta primary antibodies
  • Description
    Rabbit monoclonal [EP1113Y] to TNF beta
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues near the N term of TNF beta (Human)

  • Positive control
    • Recombinant TNF beta
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab52639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Detects a band of approximately 18 kDa (predicted molecular weight: 22 kDa).
  • Application notesIs unsuitable for IP.
  • Target

    • FunctionCytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
    • Involvement in diseaseGenetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
    • Sequence similaritiesBelongs to the tumor necrosis factor family.
    • Cellular localizationSecreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
    • Information by UniProt
    • Database links
    • Alternative names
      • LTalpha antibody
      • DIF antibody
      • LT alpha antibody
      • LT antibody
      • LT-alpha antibody
      • Lta antibody
      • Lymphotoxin alpha (TNF superfamily, member 1) antibody
      • Lymphotoxin alpha antibody
      • Lymphotoxin-alpha antibody
      • TNF B antibody
      • TNF superfamily member 1 antibody
      • TNF, lymphocyte-derived antibody
      • TNF-beta antibody
      • TNFB antibody
      • TNFB_HUMAN antibody
      • TNFbeta antibody
      • TNFSF1 antibody
      • TNLG1E antibody
      • Tumor necrosis factor beta antibody
      • tumor necrosis factor ligand 1E antibody
      • Tumor necrosis factor ligand superfamily member 1 antibody
      see all

    Anti-TNF beta antibody [EP1113Y] images

    • Anti-TNF beta antibody [EP1113Y] (ab52639) at 1/5000 dilution + Recombinant TNF beta at 0.05 µg

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size : 22 kDa
      Observed band size : 18 kDa (why is the actual band size different from the predicted?)

    References for Anti-TNF beta antibody [EP1113Y] (ab52639)

    ab52639 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"