Recombinant
RabMAb

Anti-TNF beta antibody [EP1113Y] (ab52639)

Overview

  • Product name
    Anti-TNF beta antibody [EP1113Y]
    See all TNF beta primary antibodies
  • Description
    Rabbit monoclonal [EP1113Y] to TNF beta
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human TNF beta aa 150-250 (N terminal). The exact sequence is proprietary.

  • Positive control
    • Recombinant TNF beta
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab52639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Detects a band of approximately 18 kDa (predicted molecular weight: 22 kDa).
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
    • Involvement in disease
      Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
    • Sequence similarities
      Belongs to the tumor necrosis factor family.
    • Cellular localization
      Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
    • Information by UniProt
    • Database links
    • Alternative names
      • LTalpha antibody
      • DIF antibody
      • LT alpha antibody
      • LT antibody
      • LT-alpha antibody
      • Lta antibody
      • Lymphotoxin alpha (TNF superfamily, member 1) antibody
      • Lymphotoxin alpha antibody
      • Lymphotoxin-alpha antibody
      • TNF B antibody
      • TNF superfamily member 1 antibody
      • TNF, lymphocyte-derived antibody
      • TNF-beta antibody
      • TNFB antibody
      • TNFB_HUMAN antibody
      • TNFbeta antibody
      • TNFSF1 antibody
      • TNLG1E antibody
      • Tumor necrosis factor beta antibody
      • tumor necrosis factor ligand 1E antibody
      • Tumor necrosis factor ligand superfamily member 1 antibody
      see all

    Images

    • Anti-TNF beta antibody [EP1113Y] (ab52639) at 1/5000 dilution + Recombinant TNF beta at 0.05 µg

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 22 kDa
      Observed band size: 18 kDa (why is the actual band size different from the predicted?)

    References

    ab52639 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab52639.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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