Overview

  • Product name
  • Description
    Rabbit polyclonal to TNFAIP8
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide derived from internal sequence of Human TNFAIP8.

  • Positive control
    • HuvEc cell extract; Human breast tissue; A549 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab166804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 23 kDa.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF 1/100 - 1/500.

Target

  • Function
    Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
  • Tissue specificity
    Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
  • Sequence similarities
    Belongs to the TNFAIP8 family.
  • Developmental stage
    Expressed at high levels in the fetal liver, lung and kidney.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • GG2 1 antibody
    • Head and neck tumor and metastasis-related protein antibody
    • MDC-3.13 antibody
    • NDED antibody
    • NF-kappa-B-inducible DED-containing protein antibody
    • SCC S2 antibody
    • SCC-S2 antibody
    • SCCS2 antibody
    • TFIP8_HUMAN antibody
    • TNF alpha-induced protein 8 antibody
    • TNF induced protein antibody
    • TNF-induced protein GG2-1 antibody
    • TNFAIP 8 antibody
    • TNFAIP8 antibody
    • Tumor necrosis factor alpha induced protein 8 antibody
    • Tumor necrosis factor alpha-induced protein 8 antibody
    see all

Images

  • All lanes : Anti-TNFAIP8 antibody (ab166804) at 1/100 dilution

    Lane 1 : HuvEc cell extract
    Lane 2 : HuvEc cell extract with immunizing peptide

    Predicted band size: 23 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue labeling TNFAIP8 with ab166804 at 5 µg/ml.
  • Immunofluorescent analysis of A549 cells labeling TNFAIP8 with ab166804 at 1/100 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

References

This product has been referenced in:
  • Hu R  et al. Expression of tumor necrosis factor-a-induced protein 8 in stage III gastric cancer and the correlation with DcR3 and ERK1/2. Oncol Lett 11:1835-1840 (2016). Read more (PubMed: 26998086) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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