• Product name
  • Description
    Rabbit polyclonal to TNFAIP8
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of human TNFAIP8.

  • Positive control
    • HUVEC cells. A549 cells. Lung carcinoma tissue.



Our Abpromise guarantee covers the use of ab64988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.


  • Function
    Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
  • Tissue specificity
    Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
  • Sequence similarities
    Belongs to the TNFAIP8 family.
  • Developmental stage
    Expressed at high levels in the fetal liver, lung and kidney.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • GG2 1 antibody
    • Head and neck tumor and metastasis-related protein antibody
    • MDC-3.13 antibody
    • NDED antibody
    • NF-kappa-B-inducible DED-containing protein antibody
    • SCC S2 antibody
    • SCC-S2 antibody
    • SCCS2 antibody
    • TFIP8_HUMAN antibody
    • TNF alpha-induced protein 8 antibody
    • TNF induced protein antibody
    • TNF-induced protein GG2-1 antibody
    • TNFAIP 8 antibody
    • TNFAIP8 antibody
    • Tumor necrosis factor alpha induced protein 8 antibody
    • Tumor necrosis factor alpha-induced protein 8 antibody
    see all

Anti-TNFAIP8 antibody images

  • All lanes : Anti-TNFAIP8 antibody (ab64988) at 1/500 dilution

    Lane 1 : Extracts from HUVEC cells
    Lane 2 : Extracts from HUVEC cells with immunizing peptide at 5 µg

    Lysates/proteins at 10 µg per lane.

    Predicted band size : 23 kDa
    Observed band size : 23 kDa
    Additional bands at : 30 kDa,80 kDa. We are unsure as to the identity of these extra bands.
  • Immunofluorescence analysis of A549 cells, using TNFAIP8 antibody (ab64988) at 1/500 dilution, in the presence (right panel) and absence (left panel) of immunising peptide.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TNFAIP8 antibody (ab64988) at 1/50 dilution, in the presence (right panel) and absence (left panel) of immunising peptide. Antigen retrieval was performed by boiling in a pressure cooker for 2-3 min. A Polymer system was used for signal enhancing. Stained using DAB.

References for Anti-TNFAIP8 antibody (ab64988)

This product has been referenced in:
  • Chen L  et al. Association between the expression levels of tumor necrosis factor-a-induced protein 8 and the prognosis of patients with gastric adenocarcinoma. Exp Ther Med 12:238-244 (2016). IHC-P ; Human . Read more (PubMed: 27347043) »
  • Xing B & Ren C Tumor-suppressive miR-99a inhibits cell proliferation via targeting of TNFAIP8 in osteosarcoma cells. Am J Transl Res 8:1082-90 (2016). Read more (PubMed: 27158394) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab64988.
Please use the links above to contact us or submit feedback about this product.


Sign up