Overview

  • Product name
    Anti-TNFRSF14 antibody - Aminoterminal end
    See all TNFRSF14 primary antibodies
  • Description
    Rabbit polyclonal to TNFRSF14 - Aminoterminal end
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to 15 amino acids from near the amino terminus of human TNFRSF14

  • Positive control
    • Mouse thymus tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab47677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 31 kDa).
IHC-P Use a concentration of 1 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function
    Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
  • Tissue specificity
    Widely expressed, with the highest expression in lung, spleen and thymus.
  • Sequence similarities
    Contains 3 TNFR-Cys repeats.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • HVEML antibody
    • ATAR antibody
    • CD270 antibody
    • CD40 like protein precursor antibody
    • Herpes virus entry mediator A antibody
    • Herpesvirus entry mediator A antibody
    • Herpesvirus entry mediator antibody
    • Herpesvirus entry mediator ligand antibody
    • HveA antibody
    • HVEM antibody
    • HVEM L antibody
    • LIGHT antibody
    • LIGHTR antibody
    • TNFRSF14 antibody
    • TNFSF 14 antibody
    • TNR14_HUMAN antibody
    • TR2 antibody
    • Tumor necrosis factor receptor like gene2 antibody
    • Tumor necrosis factor receptor superfamily member 14 antibody
    • Tumor necrosis factor receptor superfamily member 14 precursor antibody
    • Tumor necrosis factor receptor-like 2 antibody
    see all

Images

  • Lane 1 : Anti-TNFRSF14 antibody - Aminoterminal end (ab47677) at 1 µg/ml
    Lane 2 : Anti-TNFRSF14 antibody - Aminoterminal end (ab47677) at 2 µg/ml

    Lane 1 : Mouse thymus tissue lysate
    Lane 2 : Mouse thymus tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 31 kDa
    Observed band size : 24 kDa (why is the actual band size different from the predicted?)
  • ab47677 at 1µg/ml staining TNFRSF-14 in mouse thymus by IHC

  • Immunofluorescence of TNFRSF14 in Mouse Thymus cells using ab47677 at 10 ug/ml.

References

This product has been referenced in:
  • Lan X  et al. Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis. Onco Targets Ther 10:919-926 (2017). Read more (PubMed: 28243127) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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