The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100.
FunctionMediates activation of NF-kappa-B. May play a role in T-cell activation.
Tissue specificityHighest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.
Sequence similaritiesBelongs to the RELT family. Contains 1 TNFR-Cys repeat.
Post-translational modificationsPhosphorylated in vitro by OXSR1.