Overview

  • Product nameAnti-TNFRSF1A antibody
    See all TNFRSF1A primary antibodies
  • Description
    Rabbit polyclonal to TNFRSF1A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 259-288 of Human TNFRSF1A (NP_001056.1).

  • Positive control
    • A549 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • Involvement in diseaseDefects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
  • Sequence similaritiesContains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • Post-translational
    modifications
    The soluble form is produced from the membrane form by proteolytic processing.
  • Cellular localizationCell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD120a antibody
    • FPF antibody
    • MGC19588 antibody
    • p55 antibody
    • p55 R antibody
    • P55R antibody
    • p60 antibody
    • TBP 1 antibody
    • TBP1 antibody
    • TBPI antibody
    • TNF R antibody
    • TNF R I antibody
    • TNF R55 antibody
    • TNF-R1 antibody
    • TNF-RI antibody
    • TNFAR antibody
    • TNFR 55 antibody
    • TNFR 60 antibody
    • TNFR antibody
    • TNFR-I antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFR60 antibody
    • TNFRI antibody
    • TNFRSF1A antibody
    • TNR1A_HUMAN antibody
    • Tumor necrosis factor alpha receptor antibody
    • Tumor necrosis factor binding protein 1 antibody
    • Tumor necrosis factor receptor 1 antibody
    • Tumor necrosis factor receptor superfamily member 1A antibody
    • Tumor necrosis factor receptor type 1 antibody
    • Tumor necrosis factor receptor type I antibody
    • Tumor necrosis factor-binding protein 1 antibody
    see all

Anti-TNFRSF1A antibody images

  • Anti-TNFRSF1A antibody (ab107860) at 1/100 dilution + A549 cell line lysates at 35 µg

    Predicted band size : 50 kDa

References for Anti-TNFRSF1A antibody (ab107860)

This product has been referenced in:
  • Al-Zoubi M  et al. Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFa completely prevents breast cancer tumor formation in vivo. Cell Cycle 12:480-90 (2013). Read more (PubMed: 23292149) »

See 1 Publication for this product

Product Wall

Thank you for your response.

Of the products which may react in canine only ab13918 has been tested in IHC and WB. However I would still recommend ab22106 as the homology of the regions is greater and it is a polyclonal antibody. You would q...

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Thank you for your response, I apologize as it seem that I lost track of the protein names. We have a few products against RANKwhichshould work with canine samples as the homologies between the protein regions is good. Of those products I would reco...

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Thank you for contacting Abcam. The alignment of the human and canine proteins are very good. As such I can offer you a testing discount for ab107860 (http://www.abcam.com/TNFRSF1A-antibody-ab107860.html) orab111119(http://www.abcam.com/TNFRSF1A-antibo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"