The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 25409517
1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 27 kDa).
1/500 - 1/1000.
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Expressed in brain, placenta, lung, skeletal muscle and kidney.
Yoshimori M et al. CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals. PLoS One9:e112564 (2014).
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Dumitriu IE et al. High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome. Circ Res110:857-69 (2012).
Read more (PubMed: 22282196) »