Overview

  • Product nameAnti-TNIK antibody
    See all TNIK primary antibodies
  • Description
    Mouse monoclonal to TNIK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-110 of Human TNIK

Properties

Applications

Our Abpromise guarantee covers the use of ab56964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSerine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading.
    • Tissue specificityExpressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
    • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
      Contains 1 CNH domain.
      Contains 1 protein kinase domain.
    • Post-translational
      modifications
      Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
    • Cellular localizationNucleus. Cytoplasm. Recycling endosome. Cytoplasm > cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC 2.7.11.1 antibody
      • KIAA0551 antibody
      • Tnik antibody
      • TNIK_HUMAN antibody
      • Traf2 and NCK interacting kinase antibody
      • Traf2 and NCK-interacting protein kinase antibody
      see all

    Anti-TNIK antibody images

    • Western blot against tagged recombinant protein immunogen using ab56964 TNIK antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    References for Anti-TNIK antibody (ab56964)

    ab56964 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56964.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"