Overview

  • Product name
  • Description
    Rabbit polyclonal to TNRC5
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Cow, Cat, Dog, Pig
  • Immunogen

    A region within synthetic peptide: GGKKSKKKSS RAKAAGGRSS SSKQRKELGG LEGDPSPEED EGIQKASPLT, corresponding to amino acids 222-271 of Human TNRC5

  • Positive control
    • Jurkat cell lysate and Human muscle tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab56238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.25 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 31 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

Target

  • Function
    Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
  • Sequence similarities
    Belongs to the canopy family.
    Contains 1 saposin B-type domain.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAG repeat containing antibody
    • CAG4A antibody
    • Canopy 3 homolog antibody
    • cnpy3 antibody
    • CNPY3_HUMAN antibody
    • CTG repeat protein 4a antibody
    • ERDA 5 antibody
    • ERDA5 antibody
    • Expanded repeat domain CAG/CTG 5 antibody
    • Expanded repeat-domain protein CAG/CTG 5 antibody
    • OTTHUMP00000016408 antibody
    • PRAT4A antibody
    • Protein associated with Tlr4 antibody
    • Protein associated with Toll like receptor 4A antibody
    • Protein canopy homolog 3 antibody
    • TNRC 5 antibody
    • Trinucleotide repeat containing 5 antibody
    • Trinucleotide repeat-containing gene 5 protein antibody
    see all

Images

  • Anti-TNRC5 antibody (ab56238) at 0.25 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 31 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
    Gel concentration: 12%
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human muscle tissue labelling TNRC5 with ab56238 at 4-8µg/ml. Arrows indicate positively labelled skeletal muscle cells. Magnification: 400X.

References

ab56238 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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