Overview

  • Product nameAnti-TNXB antibody
    See all TNXB primary antibodies
  • Description
    Rabbit polyclonal to TNXB
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A synthesized peptide derived from an internal region of Human TNXB.

  • Positive control
    • Human breast carcinoma tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS, 0.88% Sodium chloride
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionAppears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
  • Tissue specificityHighly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
  • Involvement in diseaseTenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the tenascin family.
    Contains 19 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 32 fibronectin type-III domains.
  • Developmental stageExpression levels are lower in adults than in children.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDS3 antibody
    • Ehlers Danlos like syndrome antibody
    • Growth inhibiting protein 45 antibody
    • Hexabrachion like protein antibody
    • Hexabrachion-like protein antibody
    • HXBL antibody
    • NXB2 antibody
    • Tenascin X precursor antibody
    • Tenascin XB antibody
    • Tenascin XB1 antibody
    • Tenascin XB2 antibody
    • Tenascin-X antibody
    • TENX antibody
    • TENX_HUMAN antibody
    • TN X antibody
    • TN-X antibody
    • TNX antibody
    • TNXB antibody
    • TNXB1 antibody
    • TNXB2 antibody
    • TNXBS antibody
    • VUR8 antibody
    • XB antibody
    • XBS antibody
    see all

Anti-TNXB antibody images

  • Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using 1/50 ab111270. The picture on the right is treated with the synthesized peptide

References for Anti-TNXB antibody (ab111270)

ab111270 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry free floating
Sample Mouse Tissue sections (Brain)
Specification Brain
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Verified customer

Submitted Oct 25 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"