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Tobramycin, free base
Ribosomal translation inhibitor
Inhibits ribosomal translation. Aminoglycoside antibiotic which binds 30S ribosomal subunit A, preventing functional protein production. Effective against gram-negative bacteria.
18H 37N 5O 9
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our
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References for Tobramycin, free base (ab120659)
This product has been referenced in:
et al. Amphiphilic ion pairs of tobramycin with lipoamino acids. Eur J Med Chem 46:1665-71 (2011).
Read more (PubMed: 21396748) »
et al. Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction. Antimicrob Agents Chemother 49:5112-8 (2005).
Read more (PubMed: 16304180) »
et al. Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation. EMBO J 21:760-8 (2002).
Read more (PubMed: 11847123) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"