Overview

  • Product name
    Tolcapone
  • Description
    Potent, selective, reversible COMT inhibitor
  • Biological description
    Potent, selective, reversible COMT inhibitor (Ki = 30 nM). Shows antiparkinsonian effects in vivo. Orally active.
  • Purity
    > 99%

Properties

  • Chemical name
    (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
  • Molecular weight
    273.24
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C14H11NO5
  • CAS Number
    134308-13-7
  • PubChem identifier
    4659569
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Bonifácio MJ  et al. Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. Br J Pharmacol 172:1739-52 (2015). Read more (PubMed: 25409768) »
  • McCane AM  et al. Tolcapone suppresses ethanol intake in alcohol-preferring rats performing a novel cued access protocol. Alcohol Clin Exp Res 38:2468-78 (2014). Read more (PubMed: 25257296) »
  • Boehn SN  et al. Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat. Nephrol Dial Transplant 28:2045-58 (2013). Read more (PubMed: 23543593) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145729.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up