Topotecan hydrochloride (SK&F 104864) (ab120388)

Overview

  • Product nameTopotecan hydrochloride (SK&F 104864)
  • Description
    Topoisomerase inhibitor
  • Alternative names
    • SK&F 104864
  • Biological descriptionTopoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.
  • Purity> 98%

Properties

  • Chemical name(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
  • Molecular weight457.91
  • Chemical structureChemical Structure
  • Molecular formulaC23H23N3O5.HCl
  • CAS Number119413-54-6
  • PubChem identifier60699
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.CN(C)Cc1c2cc3CN4C(=O)C=5COC(=O)[C@](O)(CC)C=5C=C4c3nc2ccc1O
  • Source

    Synthetic

  • Research areas

    Associated products

    References for Topotecan hydrochloride (SK&F 104864) (ab120388)

    This product has been referenced in:
    • Mathijssen RH  et al. Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan. Curr Cancer Drug Targets 2:103-23 (2002). Read more (PubMed: 12188913) »
    • Tanizawa A  et al. Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86:836-42 (1994). Read more (PubMed: 8182764) »

    See 0 Publications for this product

    Product Wall

    Thank you for contacting us. The lab has indicated that this compound is not in fact soluble in PBS. We do not have any internal testing on absorabce but some outside info on Topotecan hydrochloride absorabce can be found just doing a google search. Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"