Overview

  • Product nameAnti-TORC1 antibodySee all TORC1 primary antibodies ...
  • Description
    Rabbit polyclonal to TORC1
  • SpecificityThis antibody will react with isoform 1 and 2 of MECT1.
  • Tested applicationsELISA, WB more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pufferfish (Fugu), Zebrafish
  • Immunogen

    Synthetic peptide: QKQAEETAAFEEVMKD, corresponding to N terminal amino acids 19-34 of Human MECT1

Properties

Applications

Our Abpromise guarantee covers the use of ab47256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA 1/10000 - 1/40000.
WB 1/500 - 1/2000. Predicted molecular weight: 67 kDa.

Target

  • FunctionTranscriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
  • Tissue specificityHighly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
  • Involvement in diseaseA chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
  • Sequence similaritiesBelongs to the TORC family.
  • Post-translational
    modifications
    Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.
  • Target information above from: UniProt accession Q6UUV9 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • KIAA0616 antibody
    • CREB regulated transcription coactivator 1 antibody
    • CREB-regulated transcription coactivator 1 antibody
    • CRTC1 antibody
    • CRTC1_HUMAN antibody
    • FLJ14027 antibody
    • KIAA0616 antibody
    • MECT 1 antibody
    • Mucoepidermoid carcinoma translocated 1 antibody
    • Mucoepidermoid carcinoma translocated protein 1 antibody
    • TORC-1 antibody
    • TORC1 antibody
    • Transducer of CREB protein 1 antibody
    • Transducer of regulated cAMP response element binding protein 1 antibody
    • Transducer of regulated cAMP response element-binding protein (CREB) 1 antibody
    • Transducer of regulated cAMP response element-binding protein 1 antibody
    • WAMTP1 antibody
    see all

References for Anti-TORC1 antibody (ab47256)

This product has been referenced in:
  • Warner KA  et al. Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol 49:1059-66 (2013). Read more (PubMed: 24035723) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"