Overview

  • Product nameAnti-TPH2 antibody
    See all TPH2 primary antibodies
  • Description
    Rabbit polyclonal to TPH2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human, Baboon
    Predicted to work with: Mouse, Rat, Chicken, Dog, Monkey, Zebrafish
  • Immunogen

    Recombinant fragment corresponding to Human TPH2 aa 178-465.
    Database link: Q8IWU9

  • Positive control
    • IMR32 whole cell lysate U87-MG whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab125877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 56 kDa.

Target

  • Tissue specificityBrain specific.
  • PathwayAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
  • Involvement in diseaseGenetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
    Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
  • Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    Contains 1 ACT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC138871 antibody
    • ADHD7 antibody
    • FLJ37295 antibody
    • MGC138872 antibody
    • Neuronal tryptophan hydroxylase antibody
    • NTPH antibody
    • TPH 2 antibody
    • Tph2 antibody
    • TPH2_HUMAN antibody
    • Tryptophan 5-hydroxylase 2 antibody
    • Tryptophan 5-monooxygenase 2 antibody
    • Tryptophan hydroxylase 2 antibody
    see all

Anti-TPH2 antibody images

  • All lanes : Anti-TPH2 antibody (ab125877) at 1/1000 dilution

    Lane 1 : IMR32 whole cell lysate
    Lane 2 : U87-MG whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 56 kDa
    10% SDS PAGE

References for Anti-TPH2 antibody (ab125877)

ab125877 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 30 µg
Gel Running Conditions Reduced Denaturing (7.5 Bis-acrylamide)
Sample Baboon Tissue lysate - whole (Brain homogenate)
Specification Brain homogenate
Treatment Protease Cocktail
Blocking step Milk as blocking agent for 1 hour(s) and 30 minute(s) · Concentration: 5% · Temperature: 25°C
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Submitted Apr 28 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"