• Product name
  • Description
    Goat polyclonal to TPP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Dog, Chimpanzee, Cynomolgus monkey
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 201-215 of Human TPP1 (NP_000382.3).

  • Positive control
    • Human placenta lysate



Our Abpromise guarantee covers the use of ab91512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 61 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
    • Tissue specificity
      Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
    • Involvement in disease
      Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:204500]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.
    • Sequence similarities
      Belongs to the peptidase S53 family.
    • Post-translational
      Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.
    • Cellular localization
      Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cell growth inhibiting gene 1 protein antibody
      • Cell growth-inhibiting gene 1 protein antibody
      • Ceroid lipofuscinosis neuronal 2 antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease) antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile antibody
      • CLN 2 antibody
      • CLN2 antibody
      • GIG 1 antibody
      • GIG1 antibody
      • Growth inhibiting protein 1 antibody
      • LPIC antibody
      • Lysosomal pepstatin insensitive protease antibody
      • Lysosomal pepstatin-insensitive protease antibody
      • MGC21297 antibody
      • TPP 1 antibody
      • TPP I antibody
      • TPP-1 antibody
      • TPP-I antibody
      • Tpp1 antibody
      • TPP1_HUMAN antibody
      • TPPI antibody
      • Tripeptidyl aminopeptidase antibody
      • Tripeptidyl peptidase I antibody
      • Tripeptidyl-peptidase 1 antibody
      • Tripeptidyl-peptidase I antibody
      see all

    Anti-TPP1 antibody images

    • Anti-TPP1 antibody (ab91512) at 0.3 µg/ml + Human placenta lysate at 35 µg
      Developed using the ECL technique

      Predicted band size : 61 kDa
      Observed band size : 65 kDa (why is the actual band size different from the predicted?)

      Exposure time : 1 hour

    References for Anti-TPP1 antibody (ab91512)

    ab91512 has not yet been referenced specifically in any publications.

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