Overview

  • Product nameAnti-TRAF1 antibody
    See all TRAF1 primary antibodies
  • Description
    Rabbit polyclonal to TRAF1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) from TRAF1.

Properties

Applications

Our Abpromise guarantee covers the use of ab37410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.

Target

  • FunctionAdapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
  • Sequence similaritiesContains 1 MATH domain.
  • DomainThe coiled coil domain mediates homo- and hetero-oligomerization.
    The MATH/TRAF domain binds to receptor cytoplasmic domains.
    Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
  • Post-translational
    modifications
    Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4732496E14Rik antibody
    • EBI6 antibody
    • EBV induced protein 6 antibody
    • Epstein-Barr virus-induced protein 6 antibody
    • MGC:10353 antibody
    • Tnf receptor associated factor 1 antibody
    • TNF receptor-associated factor 1 antibody
    • TRAF 1 antibody
    • TRAF1 antibody
    • TRAF1_HUMAN antibody
    see all

References for Anti-TRAF1 antibody (ab37410)

This product has been referenced in:
  • Sommermann TG  et al. IKKß and NF-?B Transcription Govern Lymphoma Cell Survival through AKT-Induced Plasma Membrane Trafficking of GLUT1. Cancer Res 71:7291-300 (2011). WB ; Human . Read more (PubMed: 21987722) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"