• Product nameAnti-TRAF3 antibody
    See all TRAF3 primary antibodies
  • Description
    Mouse monoclonal to TRAF3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 298-411 of Human TRAF3



Our Abpromise guarantee covers the use of ab58368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
    • Sequence similaritiesBelongs to the TNF receptor-associated factor family. A subfamily.
      Contains 1 MATH domain.
      Contains 1 RING-type zinc finger.
      Contains 2 TRAF-type zinc fingers.
    • DomainThe MATH/TRAF domain binds to receptor cytoplasmic domains.
      The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.
    • Post-translational
      Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling (By similarity). Deubiquitinated by OTUB1, OTUB2 and OTUD5.
    • Cellular localizationCytoplasm. Endosome. Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAP 1 antibody
      • CAP-1 antibody
      • CAP1 antibody
      • CD40 associated protein 1 antibody
      • CD40 binding protein antibody
      • CD40 bp antibody
      • CD40 receptor associated factor 1 antibody
      • CD40 receptor-associated factor 1 antibody
      • CD40-binding protein antibody
      • CD40BP antibody
      • CRAF 1 antibody
      • CRAF1 antibody
      • IIAE5 antibody
      • LAP 1 antibody
      • LAP1 antibody
      • LMP1 associated protein antibody
      • LMP1-associated protein 1 antibody
      • MIPT3 antibody
      • TNF receptor associated factor 3 antibody
      • TNF receptor-associated factor 3 antibody
      • TRAF 3 antibody
      • Traf3 antibody
      • TRAF3_HUMAN antibody
      see all

    Anti-TRAF3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58368 TRAF3 antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa

    References for Anti-TRAF3 antibody (ab58368)

    ab58368 has not yet been referenced specifically in any publications.

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