Overview

  • Product name
  • Description
    Rabbit polyclonal to TRAF7
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (GPAFSAVTTI TKADGTSTYK QHCRTPSSSS TLAYSPRDEE DSMPPISTPR) of Human TRAF7 (NP_115647).

  • Positive control
    • Human fetal stomach lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 75 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.
  • Tissue specificity
    Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the WD repeat TRAF7 family.
    Contains 1 RING-type zinc finger.
    Contains 1 TRAF-type zinc finger.
    Contains 7 WD repeats.
  • Post-translational
    modifications
    Phosphorylated by MAP3K3.
    Ubiquitinates itself upon phosphorylation.
  • Cellular localization
    Cytoplasmic vesicle. Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin protein ligase TRAF7 antibody
    • E3 ubiquitin-protein ligase TRAF7 antibody
    • RFWD1 antibody
    • Ring finger and WD repeat domain 1 antibody
    • RING finger and WD repeat-containing protein 1 antibody
    • RING finger protein 119 antibody
    • RNF119 antibody
    • TNF receptor associated factor 7 antibody
    • TNF receptor-associated factor 7 antibody
    • TRAF7 antibody
    • TRAF7_HUMAN antibody
    see all

Images

  • Anti-TRAF7 antibody (ab99022) at 1 µg/ml + Human fetal stomach lysate at 10 µg

    Predicted band size : 75 kDa

References

ab99022 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab99022.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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