Anti-Transferrin Receptor antibody [OX-26] (FITC) (ab33927)


  • Product nameAnti-Transferrin Receptor antibody [OX-26] (FITC)
    See all Transferrin Receptor primary antibodies
  • Description
    Mouse monoclonal [OX-26] to Transferrin Receptor (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • SpecificityRecognizes the rat transferrin receptor (CD71). It labels dividing cells of various types but also binds to a number of non-dividing normal tissues and endothelium of brain capillaries.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    PHA-activated rat lymphocytes.

  • Positive control
    • PHA-activated rat lymphocytes.
  • General notes

    Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).



Our Abpromise guarantee covers the use of ab33927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/1. Use 10µl of the suggested working dilution to label 106 cells in 100µl.

ab91362-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


  • FunctionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
    (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
  • Involvement in diseaseImmunodeficiency 46
  • Sequence similaritiesBelongs to the peptidase M28 family. M28B subfamily.
    Contains 1 PA (protease associated) domain.
  • Post-translational
    N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
    Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
    Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
  • Cellular localizationSecreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 71 antibody
    • CD71 antibody
    • CD71 antigen antibody
    • OTTHUMP00000208523 antibody
    • OTTHUMP00000208524 antibody
    • OTTHUMP00000208525 antibody
    • p90 antibody
    • sTfR antibody
    • T9 antibody
    • TFR 1 antibody
    • TfR antibody
    • TfR1 antibody
    • TFR1_HUMAN antibody
    • TFRC antibody
    • TR antibody
    • Transferrin receptor (p90 CD71) antibody
    • Transferrin receptor protein 1, serum form antibody
    • Trfr antibody
    see all

References for Anti-Transferrin Receptor antibody [OX-26] (FITC) (ab33927)

This product has been referenced in:
  • Rathnasamy G  et al. Iron and Iron Regulatory Proteins in Amoeboid Microglial Cells Are Linked to Oligodendrocyte Death in Hypoxic Neonatal Rat Periventricular White Matter through Production of Proinflammatory Cytokines and Reactive Oxygen/Nitrogen Species. J Neurosci 31:17982-95 (2011). IHC (PFA fixed) ; Rat . Read more (PubMed: 22159112) »

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