Human Predicted to work with:
Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
Synthetic peptide corresponding to a region within the internal sequence amino acids 418-467 (KKIGRCISTK AVGSDSRVDI TDLYKYPEGS RKERQVYSKA VNRLFGVEAS) of Human Transglutaminase 6 (CAI22900; UniProt ID O95932 isoform 2).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 µg/ml. TGM6 has two isoforms- 71 and 79kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Involvement in disease
Defects in TGM6 are the cause of spinocerebellar ataxia type 35 (SCA35) [MIM:613908]. A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA35 patients commonly show upper limb involvement and torticollis. There is no cognitive impairment.
Belongs to the transglutaminase superfamily. Transglutaminase family.