FunctionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Tissue specificityUbiquitous. Abundant in skeletal muscle, heart and placenta.
Sequence similaritiesBelongs to the Mediator complex subunit 24 family.
Cofactor required for Sp1 transcriptional activation subunit 4 antibody
CRSP complex subunit 4 antibody
MED 24 antibody
Mediator complex subunit 24 antibody
Mediator of RNA polymerase II transcription subunit 24 antibody
Mediator of RNA polymerase II transcription subunit 24 homolog antibody
Thyroid hormone receptor associated protein 4 antibody
Thyroid hormone receptor associated protein complex 100 kDa component antibody
Thyroid hormone receptor-associated protein 4 antibody
Thyroid hormone receptor-associated protein complex 100 kDa component antibody
Vitamin D3 receptor interacting protein complex component DRIP100 antibody
Vitamin D3 receptor-interacting protein complex 100 kDa component antibody
References for Anti-TRAP100 antibody (ab80468)
This product has been referenced in:
Fukasawa R et al.
Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.
J Biochem158:373-84 (2015).
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