Anti-Treacher Collins syndrome protein antibody (ab57683)

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex.
    • Involvement in diseaseDefects in TCOF1 are the cause of Treacher Collins syndrome type 1 (TCS1) [MIM:154500]. It is a form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss.
    • Sequence similaritiesContains 1 LisH domain.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus > nucleolus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Mandibulofacial dysostosis antibody
      • MFD1 antibody
      • Nucleolar trafficking phosphoprotein antibody
      • TCOF 1 antibody
      • TCOF_HUMAN antibody
      • TCOF1 antibody
      • TCS antibody
      • TCS1 antibody
      • Treacher Collins Franceschetti syndrome 1 antibody
      • Treacher Collins syndrome antibody
      • Treacher Collins syndrome protein antibody
      • Treacle antibody
      • Treacle protein antibody
      see all

    Anti-Treacher Collins syndrome protein antibody images

    • Western blot against tagged recombinant protein immunogen using ab57683 Treacher Collins syndrome protein antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    References for Anti-Treacher Collins syndrome protein antibody (ab57683)

    ab57683 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57683.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"