Anti-TREM1 antibody (ab104413)
Key features and details
- Rabbit polyclonal to TREM1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-TREM1 antibody
See all TREM1 primary antibodies -
Description
Rabbit polyclonal to TREM1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant full length protein within Human TREM1 aa 1-250. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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Positive control
- Mouse kidney tissue lysate; TREM1 transfected 293T cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab104413 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa. |
Target
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Function
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. -
Tissue specificity
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 54210 Human
- Entrez Gene: 58217 Mouse
- Omim: 605085 Human
- SwissProt: Q9NP99 Human
- SwissProt: Q9JKE2 Mouse
- Unigene: 283022 Human
- Unigene: 248352 Mouse
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Alternative names
- CD354 antibody
- OTTMUSP00000018206 antibody
- TREM 1 antibody
see all
Images
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Anti-TREM1 antibody (ab104413) at 1 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 26 kDa -
All lanes : Anti-TREM1 antibody (ab104413) at 1 µg/ml
Lane 1 : TREM1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 26 kDa
Datasheets and documents
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Datasheet download
References (8)
ab104413 has been referenced in 8 publications.
- Yao L et al. Shengxian decoction decreases doxorubicin-induced cardiac apoptosis by regulating the TREM1/NF-?B signaling pathway. Mol Med Rep 23:N/A (2021). PubMed: 33495812
- Wang L et al. Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease. Int Immunopharmacol 96:107700 (2021). PubMed: 34000706
- Li J et al. Transcriptomic Profiling Reveals a Role for TREM-1 Activation in Enterovirus D68 Infection-Induced Proinflammatory Responses. Front Immunol 12:749618 (2021). PubMed: 34887856
- Feng CW et al. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci 13:769 (2019). PubMed: 31440123
- Liu F et al. TREM1: A positive regulator for inflammatory response via NF-?B pathway in A549 cells infected with Mycoplasma pneumoniae. Biomed Pharmacother 107:1466-1472 (2018). PubMed: 30257363
- Shi R et al. Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice. Int J Mol Med 41:2159-2168 (2018). PubMed: 29393375
- Tammaro A et al. Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation. Sci Rep 6:38275 (2016). PubMed: 27928159
- Tammaro A et al. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. PLoS One 8:e82498 (2013). WB ; Mouse, Human . PubMed: 24358193