Anti-TREM1 antibody [RM0138-3C66] (ab86490)
Key features and details
- Rat monoclonal [RM0138-3C66] to TREM1
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
Overview
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Product name
Anti-TREM1 antibody [RM0138-3C66]
See all TREM1 primary antibodies -
Description
Rat monoclonal [RM0138-3C66] to TREM1 -
Host species
Rat -
Specificity
This antibody detects mouse of TREM1, but not TREM2b in Western blotting. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Mouse recombinant protein of the extracellular domain of TREM1
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography. -
Clonality
Monoclonal -
Clone number
RM0138-3C66 -
Isotype
IgG2 -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab86490 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 26 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 26 kDa. |
Target
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Function
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. -
Tissue specificity
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 58217 Mouse
- SwissProt: Q9JKE2 Mouse
- Unigene: 248352 Mouse
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Alternative names
- CD354 antibody
- OTTMUSP00000018206 antibody
- TREM 1 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (1)
ab86490 has been referenced in 1 publication.
- Sun XG et al. Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage. Exp Neurol 341:113692 (2021). PubMed: 33727099